Longevity chew
NOVOS Vital
The world's first longevity chew. A daily chew built around compounds selected for their effects on ageing biology.
- Chewable format
- Formulated at NOVOS
- Compound selection from ageing research
Press
Interviews and expert commentary.
Read the articleRepublished across several international Vogue editions.Vogue
Read the articleOriginally published on The Edge by Hone Health.Miami HeraldRead the articleRepublished by Yahoo Health.Real SimpleRead the articleSubsequently cited by Infobae.Well+GoodRead the articleThe Zoe Report
Read the articleAdapted by Ngôi Sao and VnExpress.Best LifeRead the articleSuperToast / SAPO
Record
- Peer-reviewed papers
- 20
- Patents
- 2
- Google Scholar citations
- 2,147
- h-index
- 15
- First-author papers
- 3
- Years in ageing research
- 11
Products
Consumer products I designed and formulated at NOVOS, taking ageing research from the bench to your belly.
Nutrition bar
NOVOS Bar
The healthiest bar in the world. A whole-food bar designed against longevity nutrition criteria rather than taste alone.
- Whole-food base
- Formulated at NOVOS
- Designed to longevity nutrition criteria
Career
2023–now
Director, machine learning and R&D
NOVOS
Directs an ageing R&D programme: a US$500,000 budget, a three-person research team, academia-industry partnerships across four countries, and two patent applications.
Research
Topic
22 papers
- 20262026ML
Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules
Science Advances
A machine-learning approach that predicts geroprotective compounds by targeting conserved longevity-associated modules, then validates the predictions experimentally.
2026HumansPreprintAcute and 6-month vascular effects of a multi-component nutritional supplement: a randomised controlled trial
SSRN
A randomised, double-blind, placebo-controlled trial measuring what a multi-ingredient supplement does to blood vessel function, immediately and after six months.
- 20252025thought leadership
Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database
npj Aging
A methodological audit of the DrugAge database, checking how well ageing-intervention studies report their results and how large the effects really are.
2025OmicsDoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders
Aging
An ageing clock built from brain lipid measurements. It estimates biological age from postmortem brain samples and finds accelerated ageing in neurological disease.
2025Model organismsPreprintRescuing healthspan in obese, aged mice: a comparison between multi-ingredient nutraceuticals and senolytic interventions
Preprints.org
Two strategies compared head to head in old, obese mice: a multi-ingredient supplement and drugs that clear senescent cells.
- 20242024Databases
Human Ageing Genomic Resources: updates on key databases in ageing research
Nucleic Acids Research
An update on the family of open databases that ageing researchers use to look up genes, compounds and species data, including DrugAge.
2024OmicsA concerted increase in readthrough and intron retention drives transposon expression during aging and senescence
eLife
Apparent activation of jumping genes with age is largely explained by how RNA is read and spliced, not by the transposons themselves waking up.
2024thought leadershipThe impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience — through the lens of the "900-day rule"
Ageing Research Reviews
When control animals die early, a treatment can look life-extending when it is not. The paper sets out how short-lived controls distort the lifespan literature.
2024in vitroPromising effects of novel supplement formulas in preventing skin aging in 3D human keratinocytes
Nutrients
Supplement formulations tested on three-dimensional human skin cell models to see whether they slow markers of skin ageing.
- 20232023Humans
Alpha-ketoglutarate supplementation and biological age in middle-aged adults (ABLE) — intervention study protocol
GeroScience
The published protocol for a randomised, double-blind, placebo-controlled trial testing alpha-ketoglutarate against epigenetic and functional measures of ageing.
- 20222022Model organisms
A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans
GeroScience
A compound that reproduces some effects of eating less, extending lifespan in the nematode C. elegans.
- 20212021Humans
Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging
Aging
Users of an alpha-ketoglutarate and vitamin formulation showed, on average, an eight-year lower biological age on a DNA methylation test after roughly seven months.
- 20202020Model organisms
Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation
npj Aging and Mechanisms of Disease
Hydrogen sulfide extends life and health in worms through a route separate from the classic dietary-restriction mutation.
2020DatabasesSynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes
Scientific Data
An open database of what happens when two longevity genes are altered together: the effects can add up, cancel out, or reverse.
- 20192019Model organisms
Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta
eLife
In worms carrying human amyloid beta in their neurons, metabolic stress appears first, before the damage usually blamed on the protein itself.
- 20182018Model organisms
Drug synergy slows aging and improves healthspan through IGF and SREBP lipid signaling
Developmental Cell
Combining drugs that act on different ageing pathways slows ageing more than either drug alone, working through IGF and lipid signalling.
2018DatabasesHuman Ageing Genomic Resources: new and updated databases
Nucleic Acids Research
The reference description of the Human Ageing Genomic Resources, the most cited paper in this record.
2018Model organismsA novel vibration-induced exercise paradigm improves fitness and lipid metabolism of Caenorhabditis elegans
Scientific Reports
A way to make worms exercise, using vibration, that improves their fitness and changes how they handle fat.
- 20172017Databases
The DrugAge database of aging-related drugs
Aging Cell
DrugAge, created here and curated for six years afterwards: 1,316 entries covering 418 compounds across 27 model organisms, drawn from 324 publications.
2017MLMachine learning for predicting lifespan-extending chemical compounds
Aging
The first published supervised model trained on DrugAge to predict whether a compound extends C. elegans lifespan. Median AUC 0.800, and 6,802 external compounds ranked.
- 20162016in silico
Systematic analysis of the gerontome reveals links between aging and age-related diseases
Human Molecular Genetics
A systematic look at the genes known to affect ageing, and how they connect to the diseases that come with age.
- 20152015Databases
Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease
Aging
A curated database of interventions studied for ageing and age-related disease.
